Neurons Receptors and the Endocannabinoid System

Over the past months, I realized that explaining to my clients how these signaling messenger cannabinoids work in their pets system seems to go right over their head and I come across as if I am speaking a different language to them, understandably so as the science is quite complex on multiple levels so the visual helps tremendously.
Endocannabinoids and their receptors are found all through out our pets body, in their connective tissues, brain, glands and immune cells and how it synergistically works in the central nervous system and every organ. Each receptor in our pets body are activated by neurotransmitters, these chemical messengers travel from one brain cell to another before attaching to the specific receptor, each has an intricate pocket that a particular neurotransmitter fits signaling messages.

Our pets natural messenger cannabinoids are anandamide and 2-AG, anandamides effects occur in the central or peripheral nervous system. The 2-AG is an endocannabinoid, an endogenoius agonist of the CB1 receptor. It is an ester formed from the omega-6 fatty acid at high levels in the central nervous system, when released within the body these two endocannabinoids, or signaling molecules bind into the CB1 and CB2 receptors, activating them to heal the body.

Our next blog will cover how our pets process Cannabidiol and Tetrahydrocannabioids and introducing a botanical therapy for them.

To your Pets!
Goldie Berencsi






As research continues in animal use we have a lot to learn and understand about this powerful herb and its healing effects for our pets, so here are some starting points for you to understand some of the science and role it plays in your pets system.

Your pets ECS (endocannabinoid system) is systemic , it's everywhere and all through their system. Their natural messenger cannabinoids are anandamide and 2-AG, anandamide's effects occur in the central or peripheral nervous systemTheir main cannabinoid receptors in the endocannabinoid system are the CB 1 and CB 2 receptors that are naturally occurring (endogenous) receptors concentrated in areas of the brain and the peripheral nervous system., this system of receptors and internal ligands are chemical signals that bind with those receptors that modify the disease processes. These cannabinoid molecules found in cannabis are exogenous ligands to the CBD receptor family anandamide (a naturally occurring messenger cannabinoid or neurotransmitter) so it binds to more cannabinoid receptors and are found naturally inside the brain and body. Are you still with me?
So we are augmenting the endocannabinoids that we produce internally and asking that  receptor system to respond in a positive way to modify that physiology in certain conditions.

In therapeutic use, CBD alone is less effective than the whole plant as it lacks the secondary cannabinoids that are in the resin offering the entourage effect. In 2001 John McPartland and Russo published a paper in the Journal of Cannabis Therapeutics applying the “entourage” concept to the plant itself. “Good evidence shows that secondary compounds in cannabis may enhance the beneficial effects of THC... and reduce THC-induced anxiety cholinergic deficits, and immunosuppression,” they wrote. “Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.” 

Our pets fully experience the "entourage" concept as well, I look forward to sharing more next week!

To your Pets!

Goldie Berencsi